Figure 2. Pathogens collected from children with acute otitis media from rural Kentucky (1992-1994) who either had not received antibiotics for at least 3 days (n=220) (top) or were treated within the past 3 days (n=63) (bottom). Plus sign indicates -lactamase positive; minus sign, -lactamase negative; asterisk, minimum inhibitory concentration (MIC) 2.0 µg/mL; dagger, MIC >0.06-1.0 µg/mL; and double dagger, MIC 0.06 µg/mL (reproduced from Block et al,³ with permission).