Figure 2. Comparison of the effect of pseudoephedrine hydrochloride plus acetaminophen vs placebo on the weighted average of pain, pressure, and congestion attributed to the paranasal sinuses. Assessments were made using a 5-point scale (0, absent; 1, mild; 2, moderate; 3, moderately severe; and 4, severe) after each of 2 treatment doses 6 hours apart. Data represent mean ± SEM change from pretreatment baseline. Statistical significance was determined a priori to be satisfied if P .029 at the second interim analysis.