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Angiogenesis and Allograft Rejection

David M. Briscoe

In this review, the authors discuss the intriguing mechanistic and functional interrelationship between the angiogenesis reaction, cell-mediated immune inflammation, and allograft rejection. They discuss evidence that angiogenesis is a component of allograft rejection, and they review data suggesting that monocytes, as well as T cells, can elicit an angiogenesis reaction in the course of recruitment into an allograft. Some angiogenesis factors, including vascular endothelial growth factor (VEGF), are proinflammatory, whereas others have antiinflammatory properties. Angiogenic factors, including VEGF and fibroblast growth factor, are known to be expressed in allografts undergoing acute rejection and are associated with the development of chronic rejection. It is likely that future research will elucidate a function for angiogenesis in allograft rejection, especially chronic rejection.

Key Words: angiogenesis • vascular endothelial growth factor (VEGF)

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