Polymorphism Study of the Insulin Receptor Substrate IRS1 and IRS2 Genes  Associated with Type 2 Diabetes in Ethnic Groups of Djerba Island

T. Baroudi Ouederni; J. Sanchez-Corona; A. Fadiel; T.  Johnson-Scalise; A. Beeghly-Fadiel; S. Flores Martinez; H. Ben Maiz; H. Kammoun Abid; H. Aounallah Skhiri; A. Benammar-Elgaaied; A.  Hamza

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Clinical Medicine Reviews in Vascular Health

Polymorphism Study of the Insulin Receptor Substrate IRS1 and IRS2 Genes Associated with Type 2 Diabetes in Ethnic Groups of Djerba Island

T. Baroudi Ouederni, J. Sanchez-Corona, A. Fadiel, T. Johnson-Scalise, A. Beeghly-Fadiel, S. Flores Martinez, H. Ben Maiz, H. Kammoun Abid, H. Aounallah Skhiri, A. Benammar-Elgaaied and A. Hamza

Clinical Medicine Reviews in Vascular Health 2010:2

Original Research

Published on 12 Aug 2010

DOI: 10.4137/CMRVH.S3378

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Abstract

Aim: We aimed to evaluate the influence of the Gly972 Arg and Ala513Pro variants of the insulin receptor substrate1 gene (IRS1) and the Gly1057 Asp variant in IRS on type 2 diabetes mellitus (T2DM) in Arab and Berber men and women from Djerba Island, Tunisia.

Methods: Genotypes, allelic and genotypic frequencies were studied. The amplified products were analyzed by Restriction Fragment Length Polymorphism (RFLP) methods by comparing T2DM with healthy controls from the same ethnicity.

Results: No differences in genotype or allelic frequencies were found between T2DM and healthy controls in either Arab or Berber ethnic groups.

Conclusion: The Gly972 Arg and Ala513Pro variants in IRS1 and Gly1057 Asp in IRS2 polymorphisms are not associated with T2DM in the Arab or Berber populations of Djerba Island

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