γ-Secretase: A Catalyst of Alzheimer Disease and Signal Transduction

Pathological pathways of AD and potential sites of therapeutic intervention. It is hypothesized that Aβ plays the most important role in the initiation of the neuropathogenesis of AD. Other factors also contribute to the onset and progress of the disease. Amyloid plaques and neurofibrillary tangles are hallmarks of the disease. Therapies that might reduce Aβ production, mitigate plaque formation, or otherwise interfere with the progression of AD are indicated in blue.