γ-Secretase: A Catalyst of Alzheimer Disease and Signal Transduction

The amyloid precursor protein (APP) can undergo multiple cleavage events. Aβ is derived from APP by β- and γ-secretase–mediated cleavage. Like α-secretase, BACE2 probably cleaves within the Aβ sequence and prevents formation of the Aβ40 and Aβ42 peptides that lead to amyloid plaques.