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Pharmacologically Directed Cell Disposal: Labeling Damaged Cells for Phagocytosis as a Strategy against Acute Pancreatitis
Table 1
Proteins Expressed by Pancreatic Acinar Cells Possibly Useful as Specific Acinar Cell Markersa
| Protein Family | Protein | Function | Subcellular/Tissue distribution | Induction in AP? | References |
|---|---|---|---|---|---|
| Stress-related secretory proteins | PAP-1 | Anti-inflammatory; antiapoptotic | Secreted from zymogen granules (ZG) | Yes | (52) |
| Molecular chaperones | Orp150 | Oxygen-sensitive inducible chaperone; cytoprotective | ER; surface of PM; cytoplasm; mitochondria | Yesb | (53, 54) |
| Heat-shock protein | HSP-72 | Stress-inducible chaperone, produces immunomodulatory effects | Cell surface and secreted | Yesc | (54) |
| TMEM49 family | VMP-1 | Essential for the induction of autophagy | Transmembrane (vacuolar membrane, ER and PM) | Yes | (7, 52) |
| Ionic channels | TALK-1 and 2 | Outward rectifying potassium channels | Trans-PM | Constitutive | (55) |
| Notch signaling pathway | DLL-1 | Notch receptor ligand | Trans-PM | Yes | (56) |
| FAM69 family | PIP49 | Unknown | Trans-PM | Yes | (57) |
| CD225 family | IP-15 | Anti-proliferative | PM | Yes | (52, 58) |
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↵a Supplemental data for this Table are available in the online version of this article (www.molinterv.org).
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↵b Constitutively expressed in pancreatic islets and in acinar cells. Increased expression in AR42J after treatment with CCK.
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↵c Increased expression in AR42J after treatment with CCK.
