Networking with AKAPs

AKAP79/150 forms customized signaling complexes. Different combinations of enzymes and substrates are anchored by AKAP79/150. A. PKA stimulates calcium channel (Ca_v1.2) currents while also negatively regulating the action of adrenergic receptors and adenylyl cyclase, which are responsible for PKA activation. B. Signaling through the M1 muscarinic receptor activates PKC which phosphorylates and terminates M-current through the potassium channel KCNQ2. C. SAP97 recruits AKAP79/150 and its anchored enzymes PP2B and PKA, whose opposing actions regulate amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) current through GluR1.