Classification of ERβ-Selective Compounds
Classes of ERβ-Selective Compounds | |||
---|---|---|---|
I. ERβ-selective binder | II. ERβ-selective activator | III. Ligand-independent ERβ selective activator | |
Properties | Highly selective binding to ERβ | Binds ERα and ERβ; induces a transcriptionally active form of ERβ | Does not bind ERβ selectively; activates ERβ via cellular kinases |
Example compound | ERB-041![]() |
liquiritigenin (component of MF101)![]() |
3,3′-diindolylmethane (DIM)![]() |
Origin | Synthetic | Glycyrrhiza uralensis | Brassica vegetables |
Ongoing or completed clinical trials | 7 | 3 | 9 |
Conditions or indications | Interstitial Cystitis, Crohn’s Disease, Endometriosis, Rheumatoid Arthritis | Menopausal Symptoms: Hot flashes | Prostate Cancer, Cervical Dysplasia, Cervical Cancer, Breast Cancer, Papilloma |