Molecular Mechanisms of SERT in Platelets: Regulation of Plasma Serotonin Levels

SERT integration into the platelet plasma membrane. Twelve intramembrane domains are predicted for SERT. Sites of glycosylation are indicated at extracellular asparagine residues. The cytoplasmic C-terminal domain contains important regulatory sequences. The SITPET hexapeptide (red residues) is key to SERT trafficking and regulation, putatively providing sites for sequential phosphorylation and interaction with cytoskeletal elements (e.g., vimentin). Residues indicated in green have been implicated in the binding of Rab 4. (See text for details.)