Fractalkine/CX3CL1: A Potential New Target for Inflammatory Diseases
Figure 2
Fractalkine/CX3CL1: Sequential steps involved of chemotaxis. Schematic mechanism of fractalkine/CX3CL1 chemotaxis. When fractalkine/CX3CL1 is present, the chemokine domain is presented at the top of the membrane-bound mucin-like stalk, where it acts as an adhesion molecule. Immobilized frac-talkine/CX3CL1 exhibits rapid and high-affinity binding to CX3CR1 (10). Interaction between fractalkine/CX3CL1 and CX3CR1 can increase integrin affinity, which results in firmer adhesion (16). Soluble fractalkine/CX3CL1 binds to CX3CR1, aiding leukocyte extravasation through the vascular wall and into the tissue (10).
