Regulation of ABC Transporters at the Blood-Brain Barrier: New Targets for CNS Therapy
Figure 3
Regulation of BBB ABC transporters by nuclear receptors. Xenobiotic- and therapeutic-drug–mediated activation of the nuclear receptors pregnane X receptor (PXR), farnesoid X receptor (FXR), and constitutive androstane receptor (CAR) increases the expression of multiple ABC transporters at the BBB, creating a regulatory network.
