New Therapeutic Approaches to Combat Arterial Thrombosis
Figure 4
Old and new targets for anti-platelet drugs
The current anti-platelet drugs target cyclo-oxygenase 1 (COX-1), the P2Y12 receptor, platelet glycoprotein IIb–IIIa (GpIIb–IIIa), and phosphodiesterase (PDE). Many of the drugs under development have new targets on the platelet, including the thromboxane A2 receptor subtype α (TPα), PAR-1 receptor for thrombin, 5-HT2A receptor for serotonin, and platelet glycoprotein Ib–IX–V (VWF receptor) and glycoprotein VI (collagen receptor).
