CHK1 Inhibitors in Combination Chemotherapy
Figure 4
Multiple CHK1 inhibitors and compensatory activation pathways
Multiple CHK1 inhibitors promote compensatory activation of the RAS-SRC / MEK1/2 / ERK1/2 pathway. The survival pathway can be inhibited at various points along its course that reveals the true toxicity of CHK1 inhibitor exposure. Killing is mediated via the intrinsic / mitochondrial cell death pathway.
