Inhibition of Nuclear Factor Kappa B (NF-B):

Diseases and conditions that may be alleviated by specific NF-κB–inhibiting drugs. Evidence from many distinct in vivo models demonstrates that the development of drugs selectively targeting NF-κB activity may yield pharmacologically relevant and therapeutically valuable treatments for a wide range of diseases and conditions in which inflammation plays a critical role. Some of the diseases that have been effectively treated by inhibitors of NF-κB in animal models are depicted.