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Coming of Age:Anti–Cytokine Therapies
Figure 2.
Categories of biologics that can target cytokines. Cytokine-blocking biologics include antibodies and receptor-derived constructs, and natural antagonist proteins. Clinically successful examples from each category are given: A-D, monoclonal antibodies; E, an immunoadhesin (consisting of two extracellular cytokine receptor domains fused with immunoglobulin constant heavy domains); and F, recombinant form of the naturally occurring IL-1 receptor antagonist. See text and Table 1 for details.
