REELIN and Schizophrenia:

RELN mRNA and RELN metabolites (50 kDa) in frontal cortex are increased following treatment of heterozygous reeler mice with valproic acid. Valproic acid (100 mg/kg) was administered subcutaneously twice a day for 15 days. A) RELN mRNA was measured by quantitative RT-PCR (4); each value is the mean ± SEM of 5 animals; B) RELN-like immunoreactive peptides; representative western blot analysis of vehicle (VEH) and valproic acid treated animals.