Layer | mRNA | Mean | ||
---|---|---|---|---|
NPS | SP | ANOVA | ||
Data show the mean numbers of RELN or DNMT positive neurons in non-psychiatric subjects (NPS) and schizophrenia patients (SP). The in situ hybridization was performed on tissue that had a post-mortem interval (PMI) of between 5 and 7 hr. ANOVA=NPS vs SP: Cell number = #/mm2 x 10−3; NS = there is no statistically significant difference between groups: groups include 3 NPS and 7 SP. | ||||
For details of in situ hybridization histochemical methods, see (46). | ||||
I | Reelin | 1.87 | 0.72 | <.001 |
Dnmt 1 | 1.13 | 1.74 | <.001 | |
II | Reelin | 2.63 | 1.17 | <.001 |
Dnmt 1 | 2.23 | 3.37 | <.002 | |
III | Reelin | 1.63 | 0.79 | <.001 |
Dnmt 1 | 2.03 | 2.94 | NS | |
IV | Reelin | 1.57 | 1.10 | <.028 |
Dnmt 1 | 2.23 | 3.60 | <.018 | |
V | Reelin | 1.53 | 1.03 | <.001 |
Dnmt 1 | 1.77 | 2.84 | <.040 | |
VI | Reelin | 1.37 | 1.07 | <.010 |
Dnmt 1 | 2.30 | 3.23 | NS | |
PMI (hr) | 6.6 | 6.14 | NS |