Table of Contents

Reviews

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  • Fulvio D'Acquisto,
  • Michael J. May,
  • and Sankar Ghosh

  Inhibition of Nuclear Factor Kappa B (NF-B):: An Emerging Theme in Anti-Inflammatory Therapies

  Mol Interv February 2002 2:22-35; doi:10.1124/mi.2.1.22
  • Abstract
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  Nuclear factor κB (NF-κB) regulates the transcription of a number of proinflammatory mediators. NF-κB turns out to be an important target of traditional anti-inflammatory agents (like aspirin), and has been singled out for targeting by a new generation of drugs.

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  • Xiao-yu R. Song,
  • Theodore J. Torphy,
  • Don E. Griswold,
  • and David Shealy

  Coming of Age:Anti–Cytokine Therapies

  Mol Interv February 2002 2:36-46; doi:10.1124/mi.2.1.36
  • Abstract
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  Immune disorders that are supported by the action of cytokines are now giving way to novel therapeutics. The potential of biopharmaceuticals is transitioning into reality within the context of many diseases.

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  • E. Costa,
  • Y. Chen,
  • J. Davis,
  • E. Dong,
  • J.S. Noh,
  • L. Tremolizzo,
  • M. Veldic,
  • D.R. Grayson,
  • and A. Guidotti

  REELIN and Schizophrenia:: A Disease at the Interface of the Genome and the Epigenome

  Mol Interv February 2002 2:47-57; doi:10.1124/mi.2.1.47
  • Abstract
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  Silencing of the Reelin gene may contribute to the etiology of schizophrenia. Investigations of Reelin and of the epigenetic mechanisms that regulate neurodevelopmental genes may provide approaches to treating psychiatric illness.