LXR Regulation of Genes Involved in Lipid Metabolism
Target Gene | Target Tissues | Function | LXRE | Species | References |
---|---|---|---|---|---|
N/A: LXRE has not been identified yet. | |||||
→→ | |||||
CYP7A1 | liver | bile acid synthesis | TGGTCActcaAGTTCA | rat | 4, 8, 14 |
TGGTCAcccaAGTTCA | mouse | ||||
TGGTCAtccaAGTTCA | hamster | ||||
TTGTCAaccaAGCTCA | human | ||||
ABCA1 | macrophage | cholesterol efflux | AGGTTActatCGGTCA | human | 12, 20– 22 |
intestine | GGATCAcctgAGGTCA | ||||
AGATCActtgAGGTCA | |||||
AGGTTActgaAGGCCA | |||||
ABCG5/G8 | liver, intestine | sterol transport | N/A | 24, 59 | |
ABCG1 | macrophage | cholesterol efflux | TGGTCActcaAGTTCA | human | 29, 31 |
AGTTTAtaatAGTTCA | |||||
APOE | macrophage | component of lipoprotein particles | GGGTCActggCGGTCA | human | 34 |
adipocyte | GAATCActtaAGGTCA | ||||
LPL | liver | triglyceride hydrolysis | AGGTCAccacCGGTCA | mouse | 37, unpublished |
macrophage | AGGTGActgcAGGTCA | human | observation | ||
CETP | - | cholesterol ester transfer | GGGTCAttgtCGGGCA | human | 36 |
SREBP-1c | liver, fat | fatty acid synthesis | GGGTTActggCGGTCA | mouse | 42– 44 |
intestine | GGGTTActagCGGGCG | ||||
LXRα | macrophage | cholesterol sensor | AGGTTActgcTGGTCA | human | 51, 52 |
YZ-2 | liver | pyrimidine metabolism (?) | N/A | unpublished | |
observation |