The GoLoco Motif: Heralding a New Tango Between G Protein Signaling and Cell Division

GoLoco motifs in a diverse set of signaling regulatory proteins. Domain organization of single- (A) and multi-GoLoco (B) containing proteins as described by the Simple Modular Architecture Research Tool (SMART, http://smart.embl-heidelberg.de). C. Multiple sequence alignment of the nineteen-residue core GoLoco motif from indicated proteins. Conserved residues within the motif are boxed. Residues that form the N-terminal α-helix in the RGS14 GoLoco/Gα_i1 crystal structure are denoted by “α” symbols. Arrowheads denote the highly conserved Asp/Glu-Gln-Arg triad. Peptide sequences were derived from GenBank and SWISS-PROT database records as denoted on right.