Members of the Erbb Ligand Family Shed by Metalloproteinases
ErbB Ligand Precursors | Ligand Binding Specificity | Candidate Metalloproteinase | Data Implicating Metalloproteinase(s) in ErbB Ligand Shedding | References |
---|---|---|---|---|
AR, amphiregulin; MMP, matrix metallproteinase | ||||
aras- and myc-transformed embryonic fibroblasts | ||||
b ADAM10 antisense strategy did not directly examine HB-EGF processing. | ||||
cprotease-inactive. | ||||
d NRG-1 isoforms | ||||
Amphiregulin | ErbB1 | ADAM17/TACE | Loss of AR processing in Tace ΔZn/ΔZn fibroblastsa and restoration by TACE overexpression | (16) |
TGFα | ErbB1 | ADAM17/TACE | Loss of TGFα processing in Tace ΔZn/ΔZn keratinocytes and restoration by TACE overexpression | (16) |
In vitro cleavage of soluble proTGFα and TGFα peptides | ||||
Loss of TPA-induced TGFα processing in Tace ΔZn/ΔZn fibroblastsa | (24) | |||
Loss of TGFα processing in Tace ΔZn/ΔZn fibroblastsa | (17) | |||
In vitro cleavage of TGFα juxtamembrane peptide | ||||
HB-EGF | ErbB1, ErbB4 | ADAM9/Meltrinγ | Overexpression of ADAM9 and mutants in Vero cells | (44) |
ADAM10/Kuzbanian | Antisense inhibited the lipoteichoic acid- (LTA)-induced transactivation of ErbB1 in NCIH292 cellsb | (43) | ||
ADAM12/Meltrinα | Overexpression of ADAM12 and inactive mutantsc in HT1080 cells | (42) | ||
ADAM17/TACE | Loss of HB-EGF processing in Tace ΔZn/ΔZn fibroblastsa and restoration by TACE overexpression | (16) | ||
Loss of TPA-induced HB-EGF processing in Tace ΔZn/ΔZn fibroblastsa | (24) | |||
MMP-3 | In vitro cleavage of HB-EGF-AP chimera with MMP-3 | (45) | ||
MMP-7 | In vitro cleavage of HB-EGF with recombinant MMP-7 | (46) | ||
Neuregulinα2cd | ErbB3, ErbB4 | ADAM17/TACE | Loss of TPA-induced NRGα2c processing in Tace ΔZn/ΔZn fibroblastsa restoration by TACE overexpression | (25) |
Neuregulinβ1 and β4c | ErbB3, ErbB4 | ADAM19 | Overexpression of ADAM19 and inactive mutantsc | (47) |