Selection of Possible Targets for Tumor Therapy by siRNAs
Genes or Fusion Genes | Aberration | Tumors |
---|---|---|
RAS | Point mutations | Pancreatic carcinoma, chronic leukemia, colon carcinoma, lung cancers |
c-MYC, N-MYC | Overexpression, translocation, Point mutation, amplification | Burkitt’s lymphoma, neuroblastoma |
ERBB | overexpression | Breast cancer |
ERBB2 | Overexpression | Breast cancer |
MLL fusion genes | Translocation | Acute leukemias |
BCR-ABL | Translocation | Acute and chronic leukemia |
TEL-AML1 | Translocation | Childhood acute leukemia |
EWS-FLI1 | Translocation | Ewing sarcoma |
TLS-FUS | Translocation | Myxoid liposarcoma |
PAX3-FKHR | Translocation | Alvelolar rhabodomyosarcoma |
BCL-2 | Overexpression, translocation | Lung cancers, Non-Hodgkin lymphoma, prostate cancer |
AML1-ETO | Translocation | Acute leukemia |