Protein Origami

Table 1.

Disorders Believed to be Related to Misfolded Proteins

Diseases	Proteins Involved
*Misrouting:*
Cystic Fibrosis	CFTR (chloride channel)
Systemic Amyloidosis	Amyloid fibrils, light chain variable domains
I-cell Disease	Unknown
Nephrogenic Diabetes Insipidus	Aquaporin-2, V-2 Receptor
Cancer	P53 protein
Hypogonadotropic hypogonadism	GnRHR
Retinitis Pigmentosa	Rhodopsin, carotenoid receptors
Emphysema	Alpha 1 antitrypsin
Alpha 1 Antitrypsin Deficiency	Alpha 1 antitrypsin
Liver Disease
*Aggregation:*
Alzheimer Disease	Amyloid, Tau protein
Creutzfeldt-Jakob	Amyloid
Spongiform Encephalopathies	Prion glycoprotein (PrP)
Sickle Cell Anemia	Hemoglobin
Parkinson Disease	Alpha-synclein, Parkin, ubiquitin C, crystallins
Cataracts	Lens crystallins
*Dominant Negative:*
Hypertrophic Cardiomyopathy	Troponin T