Apolipoprotein E, Amyloid, and Alzheimer Disease

Neuritic plaques (as determined by the de Olmos silver stain) in APP^V717Ftransgenic mice with and without apoE (at fifteen months of age). APP^V717F transgenic mice that express apoE have nearly twenty-five times more neuritic plaques compared to mice without apoE. Inset: Large arrow points to a large, distended, dystrophic neurite in a plaque, and small arrow points to fine dystrophic neurites. Adapted from (43).