The TASK Family: Two-Pore Domain Background K+ Channels

Expression of TASK-1 and TASK-3 channels in rat brainstem, heart and adrenal gland. Sections of rat brainstem (upper), heart (middle), and adrenal gland (lower) were hybridized with [³³P]-labeled cRNA antisense probes complementary to TASK-1 (left) and TASK-3 (right). High levels of TASK-1 and especially TASK-3 mRNA in hypoglossal motoneurons in rat brainstem are observed (arrows). In the rat heart, TASK-1 (but not TASK-3) is predominantly expressed. In the adrenal gland (bottom), TASK-1 transcripts are evident in all regions whereas TASK-3 transcripts are expressed at high levels in the outermost layers (zona glomerulosa and fasciculata) and in the adrenal medulla.