Epigenetic Downregulation of GABAergic Function in Schizophrenia: Potential for Pharmacological Intervention?

A model for reelin-mediated activation of mRNA translation in pyramidal neuron dendritic spines. Reelin secreted from GABAergic interneurons by a constitutive mechanism interacts with an integrin receptor initiating a cascade that activates translation of spine-resident mRNAs. Reelin is located on postsynaptic densities and initiates a signaling cascade involving the activation of focal adhesion kinase (FAK), phosphorylation of DAB1 and subsequently cytoplasmic polyadenylation element binding protein (CPEB), mRNA polyadenylation and subsequent translation. (Modified from 53.)