Epigenetic Downregulation of GABAergic Function in Schizophrenia: Potential for Pharmacological Intervention?

The downregulation of RELN and GAD1 by methionine (MET) in mice is normalized by valproate (VPA).l-Methionine (MET, 6.6 mmol/kg s.c.), valproate (VPA, 2 mmol/kg s.c.) or vehicle (VEH, 0.1 ml/10 g of body weight, s.c.) was administered twice a day for 15 days. RNA was isolated from the frontal cortex and mRNAs were quantified using competitive RT-PCR with internal sequence-specific RNA standards. For details see Tremolizzo et al. (50).