Serotonin 5-HT₂ Receptors: Molecular and Genomic Diversity

Table 2.

Association Studies with SNPs of the Human 5-HT2A and 5-HT2C Receptors

SNP	MDD	Suicide	SAD	Sp.–CLZ	Sp.–TD	BD	WG/ED	AD	ALC
			Response
This polymorphism is in complete linkage disequilibrium with the silent T102C polymorphism, therefore the results of an association study with one SNP are true for the other SNP and all existing data will be reported for the -1438A/G SNP. *This haplotype consists of -1,027(GT)₁₄ , -995A, -759T, -697C. References for observed reports are given as superscripted numbers. MDD, Major Depressive Disorder; SAD, Seasonal Affective Disorder; Sp–Clz Response, Schizophrenia–Clozapine Response; Sp–TD, Schizophrenia–Tardive Dyskinesia; BD, Bipolar Disorder; WG/ED, Weight Gain/Eating Disorder; AD, Alzheimer’s Disease; ALC, Alcoholism; Neg., negative association; Pos., positive association; Mix, reports of positive and negative association; NS: not studied.
*5-HT_2A Receptor*
-1438A/G*	Neg.⁵⁹	Mix^58,64,80	Mix^62,63,64	Pos.⁶⁵	Mix^69,71,72	Neg.^73,74,75	Mix^77,78,79	Mix^88,89	Mix^86,87
C516T	NS	NS	NS	NS	NS	Neg.^74,75	Neg.⁷⁷	NS	NS
T25N	NS	NS	NS	NS	NS	Neg.^74,75	Neg.^77,79	NS	NS
A447V	NS	NS	Neg.⁵⁶	NS	NS	NS	NS	NS	NS
H452Y	Neg.⁶⁰	NS	Neg.⁵⁶	Pos.⁶⁵	Neg.^71,72	Neg.^73,74,75	Neg.^77,79	NS	Neg.⁸⁶
*5-HT_2C Receptor*
Haplotype 3**	NS	NS	NS	NS	NS	NS	Pos.⁴⁶	NS	NS
-759C/T	NS	NS	NS	NS	Neg.⁷⁰	NS	Pos.⁸¹	NS	NS
-697G/C	NS	NS	NS	NS	Pos.⁷⁰	NS	Pos.⁴⁶	NS	NS
C23S	Mix^61,59	NS	Neg.⁶²	Mix^66,67,68	Pos.⁶⁹	Mix^61,90,97	Mix^82,83,84	Pos.⁵⁰	Pos.⁸⁵

Serotonin 5-HT2 Receptors: Molecular and Genomic Diversity