Selected In Vitro and In Vivo Probe Substrates for CYP Enzymes
CYP | Probe Substrate In Vitro | In Vivo |
---|---|---|
CYP1A2 | Phenacetin | Caffeine |
CYP2A6 | Coumarin | Courmarin |
CYP2B6 | Bupropion | Bupropion |
CYP2C8 | Paclitaxel | Unclear |
CYP2C9 | Diclofenac Tolbutamide S-Warfarin | Tolbutamide S-Warfarin |
CYP2C19 | S-Mephenytoin Omeprazole | S-Mephenytoin Omeprazole |
CYP2D6 | Bufurolol | Dextromethrophan |
CYP2E1 | Chlorzoxazone | Chlorzoxazone |
CYP3A4 | Midazolam Testosterone | Midazolam Erythromycin |