Fibrin(ogen) Receptors, Signaling Pathways Induced, and Biological Functions
Receptors | Recognition site | Cell type/Site of binding interaction | Fibrin(ogen)-Induced Signaling Pathway | Function |
---|---|---|---|---|
NF- κB, nuclear factor kappa B; PI3K, phosphoinositide 3-kinase; ERK1/2, extracellular signal-regulated kinase 1 and 2; PLC, phospholipase C; ICAM-1, intercellular adhesion molecule 1. | ||||
Integrins | ||||
α5β1 | Aα572–574 | Leukocytes | - | Migration (120 |
Endothelial cells | Adhesion (147) | |||
αMβ2 | γ190–202 | Neutrophils | NF-κB (148) | Adhesion (150) |
Migration (151, 152) | ||||
(Mac-1, CD11b/ CD18) | γ377–395 | |||
Monocytes | PI3K (41) | Survival (41) | ||
ERK1/2 (41, 149) | Cytokine release (42 | |||
Phagocytosis (149) | ||||
αIIbβ3 | γ400–411 | Platelets, | PLC | Adhesion (39, 153) |
γ365–383 | Megakaryocytes | |||
αvβ3 | Aα572–574 | Endothelial cells | PLC | Adhesion (154) |
Fibroblasts | Adhesion (155) | |||
αIIbβ8 | - | Schwann cells | ERK1/2 (66) | Adhesion (74) |
(73, 74) | Proliferation (66) | |||
Non-Integrins | ||||
ICAM-1 | γ117–133 | Leukocytes | Adhesion (157–160) | |
Neutrophils | Rho (156) | Migration (43) | ||
Endothelial cells | ERK1/2 (45) | Survival (45) | ||
VE-cadherin | β15–42 | Endothelial cells | - | Adhesion (161) |
Proliferation (162) | ||||
Migration (163, 164) | ||||
Capillary tube formation (46, 163) |