The Receptor Concept: A Continuing Evolution

Agonist-evoked redistribution of GPCRs. Agonist occupancy of the receptor leads to GRK-catalyzed phosphorylation, binding of arrestin, and entry into the cell via clathrin-coated pits. Receptors can either be degraded or, post-dephosphorylation, recycled to again be activated by agonist. Figure from (70). Published with permission from Elsevier Press © 1999.