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REGULATORs OF G PROTEIN SIGNALING & DRUGS OF ABUSE
Figure 1.
The G protein cycle. RGS proteins are GTPase-accelerating proteins (GAPs), accelerating the hydrolysis of GTP bound to Gα. RGS proteins thus reduce the lifetime of active Gα–GTP and βγ dimers, so that signaling pathways downstream of the G protein are held in check.
