Pharmacology of the Inhibition of NAADP-Induced Ca2+ Release
Cell/Preparation | NAADP inactivation | Ryanodine/ Ruthenium Red | 8-sub-cADPR | Heparin | Thapsigargin | Bafilomycin | DHP | References |
---|---|---|---|---|---|---|---|---|
RED, reduced; ND, not determined; 8-sub-cADPR, 8-substituted inhibitor analogs of cADPR; DHP, dihydropyridine; YES, inhibition; NO, no inhibition. | ||||||||
Sea urchin egg (homogenate) | YES | NO | NO | NO | NO | YES | YES | (3, 11) |
Sea urchin egg (intact) | YES | NO | NO | YES | NO | YES | YES | (11) |
Brain microsomes | ND | NO | NO | NO | ND | ND | YES | (40) |
Aplysia neuron | ND | NO | NO | NO | ND | ND | ND | (41) |
Frog NMJ | ND | NO | ND | NO | NO | ND | ND | (42, 43) |
Rat cortical neuron | ND | NO | ND | NO | NO | YES | ND | (44) |
Heart microsomes | ND | NO | NO | NO | ND | ND | YES | (52) |
Mesangial cells | ND | NO | NO | NO | ND | ND | YES | (60) |
Starfish oocyte | YES | NO | NO | NO | YES | ND | YES | (61) |
Ascidian oocyte | YES | NO | ND | NO | ND | ND | ND | (62) |
Rat aortic myocytes | ND | NO | NO | NO | ND | ND | YES | (51) |
Rat pulmonary arterial myocyte | ND | RED | RED? | NO | NO | YES | ND | (49, 50) |
Jurkat T cell | YES | RED | RED? | NO | ND | ND | YES | (16, 56) |
Pancreatic acinar cells | YES | YES | YES | YES | YES/RED | YES/RED | ND | (20, 28, 36) |
Pancreatic acinar cell nuclear envelope | YES | YES | ND | NO | YES | NO | ND | (35) |
Pancreatic beta cell | YES | NO | NO | NO | NO | ND | ND | (36) |
MIN6 SGs | ND | NO | NO | NO | NO | YES | YES | (48) |
MIN6 cell | YES | NO | NO | NO | NO | YES | ND | (36, 46) |
RYR1 (bilayer) | ND | YES | ND | ND | ND | ND | ND | (53) |
RYR2 (bilayer) | ND | YES | ND | ND | ND | ND | ND | (54) |
Plant microsomes | YES | YES | NO | NO | ND | ND | NO | (57) |