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Mechanism of Tissue-Selective Drug Action in the Cardiovascular System
Figure 4.
Physiological basis of corpora cavernosa smooth muscle relaxation. The NO–cGMP–protein kinase G cascade in the mechanism of penile erection is indicated. The role of PDE5 inhibition as a therapeutic target in ED is also indicated. [Modified with permission from International Education Initiative on Erectile Function Core Slide Kit, copyright Physicians World GmbH (2002).]
