Phosphoinositide Phosphatases: Emerging Roles As Voltage Sensors?

Alignment of PTEN with the Ci-VSP family. Amino acid identities are bold and boxed in dark gray whereas conserved amino acids are highlighted in light gray. The four transmembrane domains are indicated by orange ovals and are labeled S1–S4. The Arg residues (R) important for voltage sensing are red. The NhhD and CX₅R regions are indicated and the C2 domain is boxed in yellow. The Lys (K) residues in PTEN, important for membrane association, are indicated by dark purple asterisks.