SEROTONIN 5-HT_2C RECEPTOR AGONISTS: POTENTIAL FOR THE TREATMENT OF OBESITY

Expression of the 5-HT_2Creceptor in POMC neurons active in energy regulation. After treatment with d-fenfluramine, 35S-labeled 5-HT_2C receptors are apparent as clusters (upper panel) of black grains in the POMC neuronal cytoplasm (brown). The black nucleus (lower panel) reflects the immunostaining of Fos-like material following treatment with fenfluramine. Scale bar, ten microns. Excerpted with permission from (58). Copyright 2002 AAAS.