Drosophila Transgenic Models of Neurodegenerative Disease
Disease Modeled | Affected Protein | Key References |
---|---|---|
aPar-1, protease-activated receptor-1. | ||
bFMR1, Fragile X mental retardation-1. | ||
Alzheimer | tau | (61) |
Alzheimer | β-amyloid | (62, 63) |
Alzheimer | Amyloid precursor protein (APP) | (63) |
Alzheimer | Presenilin | (63) |
Alzheimer | BACE (β-site APP-cleaving enzyme) | (63) |
Alzheimer | PAR-1a | (64) |
Fragile X | FMR1b (90 rCGG repeats) | (65) |
Hereditary Spastic Paraplegia | Spastin | (66) |
Huntington | polyQ | (67) |
Huntington | Huntingtin | (16) |
Kennedy | Androgen receptor | (68) |
Machado-Joseph | Spinocerebellar ataxia type 3 (SCA3) | (18) |
Neuronal Ceroid Lipfuscinoses | Palmitoyl-protein thioesterase I | (69) |
Parkinson | α–synuclein | (1, 50, 77) |
Spinocerebellar Ataxia | SCA1 | (17) |
Spinal & Bulbar Muscular Atrophy | Androgen receptor | (19) |
Spinocerebellar Ataxia | SCA8 (Noncoding RNA) | (70) |
Spinocerebellar Ataxia type 2 | Ataxin-2 SCA2 | (71) |