Increased Expression and Function of Vascular α_1D-Adrenoceptors May Mediate The Prohypertensive Effects Of Angiotensin II

Suggested signal transduction mechanism involving Ang II-AT1 receptor and its influence on α_1D-adrenoceptor expression and function. In the orange box are conditions where Ang II levels are elevated, which favor increased α_1D-adrenoceptor expression and function. PLC, phospholipase C; PKC, protein kinase C; β-arr, β-arrestin; GRK, G protein receptor coupled kinase; Src, a tyrosine kinase.