Targeting PGE₂ Receptor Subtypes Rather Than Cyclooxygenases: A Bridge Over Troubled Water?

Arachidonic acid cascade and its physiological and pharmacological modulation. The metabolism of arachidonic acid to prostanoids is represented. Physiological regulations (right side of the figure) and pharmacological modulators (left side of the figure) are shown at different steps of the pathway. Enzymatic pathways, products, regulation, and drugs preferentially mediated by COX-1 are indicated in green, whereas items preferentially mediated by COX-2 appear in blue. Substrates, modulators, products, or drugs common to both isoenzymes are shown in red. See text for detailed explanations of abbreviations.