The integrin receptors and their major ECM ligands. Each heterodimeric transmembrane integrin receptor consists of one α and one β subunit. α subunits: α1,
α2,
α3,
α4,
α5,
α6,
α7,
α8,
α9,
α10,
α11,
αv; β subunits:
β1,
β3,
β4,
β5, •β6,
β7,
β8. Composition of each subunit determines ligand specificity. Figure depicts seventeen distinct integrins and their binding
preferences for collagen, laminin, tenascin, fibronectin, and vitronectin.