Cannabinoids Biology: The Search for New Therapeutic Targets

Passive Diffusion of Anandamide Driven by FAAH (Model 2). In this model, the sole function of FAAH (red) is to establish a concentration gradient of anandamide transport (blue arrow) through hydrolysis of anandamide into arachidonic acid and ethanolamine. FAAH is localized exclusively in the perinuclear area. Delivery of anandamide to perinuclear FAAH may require a special protein or process currently undefined.