BCL-xL Regulates Synaptic Plasticity

Drosophiladrp1mutation prevents mobilization of neurotransmitter-containing vesicles from the reserve pool. A. Labeling of distinct pools of synaptic vesicles with FM 1-43 in the wild-type synapse is achieved with different stimulation paradigms. B. In the mutant synapse, lack of mobilization of reserve pool vesicles prevents dye uptake into the reserve pool during stimulation as compared to control in A. See text for details.