Salvinorin A

Proposed KOR:salvinorin A binding complex. Views are presented through the helical bundles (A) or from the extracellular side of KOR looking into the binding pocket of KOR (B). Salvinorin A is stabilized in the binding pocket through hydrogen bonding and hydrophobic interactions with Y119 (helix 2), Y313 and Y320 (helix 7), I294 (helix 6) (shown in green), and the second extracellular loop of KOR (shown in yellow). For clarity, some helical residues are not shown; figures were constructed using PyMOL.