- Institution: Stanford Univ Med Ctr Lane Med Lib/Periodical Dept/Rm L109
- Sign In as Member / Individual
SAR by NMR: Putting the Pieces Together
Figure 2.
The SAR by NMR concept. Multiple, low molecular weight compounds (“fragments”) are identified that can simultaneously bind to proximal sites on the protein surface. Based on structural information, these fragments can be linked to produce a ligand whose binding affinity is theoretically the sum of the individual pieces.
