Cyclic Nucleotide Signaling Mechanisms in Trypanosomes: Possible Targets for Therapeutic Agents

The domain organization of predicted cAMP-binding proteins in theT. bruceigenome. Some of the proteins appear less complex, containing only a single putative cAMP-binding domain, whereas others contain more than one cAMP-binding domain. The details of possible cNMP binding to these domains remain unknown. Other proteins containing predicted cNMP-binding domains are more complex, integrating multiple domains such as the C2 domain. It is hypothesized that these proteins act as scaffolding proteins bringing together diverse cAMP-mediated signaling proteins or interact specifically with other proteins and allow their regulation under the presence of specific cAMP signals.