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Bound to Be Different: Neurotransmitter Transporters Meet Their Bacterial Cousins
Figure 2.
Schematic illustrating a mechanism for noncompetitive inhibition of LeuT by the TCAs. The cartoon labeled CMI/Occluded Complex depicts the coordination sites for clomipramine and substrate positioned in non-overlapping binding modes above and below the upper gate (salt bridge), respectively. See text for details. Adapted by permission from Macmillan Publishers Ltd: Nature448, 952–956, © 2007.
