Targeting Cancer Stem Cell Properties
Targeted process | Specific Target(s) | Phytochemical(s) [origin] |
---|---|---|
P-gp, P-glycoprotein; MRP, multidrug resistance-related protein;ABCG2, ATP-binding cassette transporter G2; MXR, mitoxantrone resistance protein; NF-κB, Nuclear factor-kappaB; RAR, Retinoic Acid Receptor. | ||
P-gp | Epigallocatechin gallate (EGCG) [green tea] | |
Drug efflux | MRP1, 4, and 5 | Quercitin [capers, apples, berries] Silymarin [blessed milk thistle] |
ABCG2 | Curcumin [tumeric] | |
P-gp, ABCG2 (MXR), and MRP1 | Tetrahydrocurcumin [tumeric] | |
Apoptosis | NF-κB | Parthenolide [feverfew] |
Differentiation | RAR | Retinoic acid [carrots, spinach, eggs] |