An experimental activity is currently underway to develop a tunable diode laser absorption tomography (TDLAT) technique to measure flow properties in a supersonic combustion wind tunnel. The present study simulates the reconstruction of spectroscopic measurements to determine the effects of data collection geometry and ambient water vapor on reconstruction accuracy. The study also proposes a way to remove the effects of ambient water vapor absorption. Overall, results show that TDLAT data collection time can be significantly reduced while maintaining reconstruction accuracy by taking fewer projections with a high density of rays and by correcting for ambient water vapor absorption.