Regular Issue

Vol. 19, No. 2, 1982

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Report | Regular issue | Vol 19, No. 2, 1982, pp.353-355
Published online:
DOI: 10.3987/R-1982-02-0353
■ Aziridine in Alkaloids Synthesis: A Novel Synthesis of Sendaverine

Hirotaka Otomasu, Kimio Higashiyama, Toshio Honda, and Tetsuji Kametani

*Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan

Abstract

A facile synthesis of 2-benzylisoquinoline alkaloid, sendaverine, has been achieved by ring opening of aziridine derivative as a key reaction.

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Report | Regular issue | Vol 19, No. 2, 1982, pp.357-361
Published online:
DOI: 10.3987/R-1982-02-0357
■ Studies on the Syntheses of Heterocyclic and Natural Compounds. Part 969. A Facile Conversion of Dehydroepiandrosterone into 16α-Hydroxypregenolone 3-Acetate

Tetsuji Kametani, Hiroko Furuyama, and Toshio Honda

*Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan

Abstract

Dehydroepiandrosterone (6) was converted into 16α-hydroxypregnenolone 3-acetate (11), employing 1,3-dipolar cycloaddition of nitrile oxide as a key reaction to give the isoxazolines (8 and 9).

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Review | Regular issue | Vol 19, No. 2, 1982, pp.363-405
Published online:
DOI: 10.3987/R-1982-02-0363
■ Advances in the Chemistry of 1,7-Naphthyridine

Marian Wozniak and Henk C. van der Plas

*Laboratory of Organic Chemistry, Agricultural University, De Dreijen 5, 6703 BC Wageningen, The Netherlands

Abstract

This review describes the physical properties of 1,7-naphthyridine and its derivatives, reports on the methods available to synthesize 1,7-naphthyridine derivatives, and discusses the reactivity of the 1,7-naphthyridine system to electrophilic and nucleophilic reagents, giving substitution and ring transformation, to N-alkylating agents, to reducing agents and to light. The review also includes a short paragraph on the pharmacogical use of 1,7-naphthyridines.

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33 data found. 31 - 33 listedFirst Previous